Sulpiride
Sulpride is an atypical antipsychotic medication classified as a benzamide derivative, primarily used to treat schizophrenia and related psychotic disorders. It works by selectively blocking dopamine D2 and D3 receptors in specific brain regions, helping to reduce positive symptoms like hallucinations and delusions. The medication is notable for having a relatively favorable side effect profile compared to many other antipsychotics, with lower rates of sedation and metabolic disturbances.
Sulpride is an antipsychotic used to treat schizophrenia that works by selectively blocking dopamine receptors with a comparatively mild side effect profile.
Key facts at a glance
- ATC
- N05AL01
- RxNorm
- 10239
- Generic
- Sulpiride
- Class
- atc-n05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Schizophrenia (both acute and chronic cases), psychotic disorders, and in some regions, depression and vertigo. It can address both positive symptoms (delusions, hallucinations) and negative symptoms (emotional withdrawal, social dysfunction).
Selective dopamine D2 and D3 receptor antagonist. By blocking these receptors in the mesolimbic pathway, it reduces dopaminergic hyperactivity associated with psychotic symptoms. At lower doses, it preferentially blocks inhibitory D2 autoreceptors, producing anxiolytic and disinhibiting effects.
May cause hyperprolactinemia leading to hormonal side effects like galactorrhea or menstrual disturbances. Has lower sedation and weight gain compared to many other antipsychotics. Contraindicated in patients with pheochromocytoma or prolactin-dependent tumors. Requires gradual dose adjustments; should not be discontinued abruptly.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy