Lenacapavir
Sunlenca (lenacapavir) is a long-acting antiretroviral medication classified as a capsid inhibitor, used in combination with other HIV medications to treat HIV-1 infection in heavily treatment-experienced adults who have limited treatment options due to drug resistance. It works by targeting the HIV capsid protein at multiple stages of the viral lifecycle, disrupting key steps needed for replication.
Sunlenca is a twice-yearly injectable HIV medication for treatment-experienced patients with limited drug options.
Key facts at a glance
- RxNorm
- 2625891
- Generic
- Sunlenca
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of HIV-1 infection in heavily treatment-experienced adults with multi-drug resistant HIV who are failing their current antiretroviral regimen. Used in combination with other antiretroviral drugs.
Sunlenca is a first-in-class capsid inhibitor that targets the HIV-1 capsid protein (p24), disrupting multiple stages of the viral lifecycle including viral assembly, nuclear import of viral DNA, and virus particle uncoating, leading to impaired viral replication.
Administered as subcutaneous injections (given every 6 months after initial loading doses). Must be used with other antiretroviral medications to form a complete regimen. Patients should be monitored for potential injection site reactions. Full prescribing information and safety data should be reviewed before initiating therapy.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy