Histrelin
Supprelin is a brand-name GnRH (gonadotropin-releasing hormone) agonist used primarily in children with central precocious puberty. It is also prescribed for certain hormone-related conditions in adults, such as prostate cancer. The medication works by initially stimulating, then suppressing the pituitary gland's production of sex hormones.
Supprelin is a GnRH agonist used to treat central precocious puberty and certain hormone-sensitive conditions by temporarily suppressing sex hormone production.
Key facts at a glance
- RxNorm
- 220125
- Generic
- Supprelin
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Supprelin is primarily used to treat central precocious puberty in children. In adults, it may be prescribed for advanced prostate cancer and other conditions where hormone suppression is therapeutically beneficial.
As a GnRH agonist, Supprelin initially stimulates the pituitary gland, causing an initial surge in gonadotropins. With continued use, it down-regulates GnRH receptors, leading to decreased secretion of LH and FSH, which ultimately reduces sex hormone production.
Supprelin is available as a subcutaneous implant or injection and should only be administered under physician supervision. Side effects may include injection site reactions, hot flashes, mood changes, and initial worsening of symptoms before improvement. Regular monitoring of hormone levels and growth parameters is essential during treatment, particularly in pediatric patients.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy