Olanzapine and Fluoxetine
Symbyax is a prescription medication that combines olanzapine (an atypical antipsychotic) and fluoxetine (an SSRI antidepressant) in a single capsule. It is FDA-approved for treating treatment-resistant depression in adults and depressive episodes associated with bipolar I disorder.
Symbyax is a combination medication used to treat depression that hasn't responded to other treatments.
Key facts at a glance
- RxNorm
- 405343
- Generic
- Symbyax
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Symbyax is used to treat treatment-resistant depression (depression that hasn't improved with other medications) and depressive episodes in adults with bipolar I disorder.
The medication combines two active ingredients: olanzapine works on dopamine and serotonin receptors in the brain, while fluoxetine increases serotonin levels by preventing its reabsorption. Together, they provide antidepressant effects for patients who haven't responded to other treatments.
Symbyax carries FDA black box warnings for increased suicidal thoughts in young adults under 25 and for antipsychotic-associated mortality in elderly patients with dementia-related psychosis. Common side effects include weight gain, increased appetite, drowsiness, and dry mouth. Patients should be monitored for metabolic changes, serotonin syndrome, and abnormal bleeding. It may take several weeks to experience full therapeutic benefits.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy