Naldemedine
Symproic (naldemedine) is a prescription medication used to treat opioid-induced constipation in adults with chronic non-cancer pain. It belongs to a class of drugs called peripherally acting mu-opioid receptor antagonists (PAMORAs) that work by blocking opioid effects in the gastrointestinal tract without reducing the pain-relieving benefits of opioid medications.
Symproic is a once-daily tablet that helps restore normal bowel function in adults taking opioid medications for chronic pain.
Key facts at a glance
- RxNorm
- 1876604
- Generic
- Symproic
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of opioid-induced constipation (OIC) in adults with chronic non-cancer pain who are taking opioid medications.
Symproic is a peripherally acting mu-opioid receptor antagonist (PAMORA). It blocks mu-opioid receptors in the gastrointestinal tract, which helps counteract the constipating effects of opioids and restores normal bowel movements without affecting central nervous system pain relief.
Common side effects may include abdominal pain, diarrhea, nausea, and headache. Patients with known or suspected bowel obstruction should not use this medication. Monitoring for symptoms of opioid withdrawal is recommended. Symproic may interact with other medications and should be taken as directed by a healthcare provider.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy