Darunavir, Cobicistat, Emtricitabine, and Tenofovir
Symtuza is a combination antiretroviral medication used to treat HIV-1 infection in adults and children. It contains multiple drugs that work together to suppress the virus, and is available as a once-daily single tablet regimen for treatment-naive patients or those who are virologically suppressed.
Symtuza is a complete HIV treatment in a single pill, combining multiple antiretroviral agents to suppress viral replication.
Key facts at a glance
- RxNorm
- 2049672
- Generic
- Symtuza
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Symtuza is indicated for the treatment of HIV-1 infection in adults and pediatric patients who meet specific criteria, typically used as a complete regimen for treatment-naive individuals or those who are virologically suppressed on another HIV regimen.
Symtuza combines four antiretroviral agents: a protease inhibitor (darunavir), a pharmacokinetic enhancer (cobicistat), and two reverse transcriptase inhibitors (emtricitabine and tenofovir alafenamide). These components work together to block multiple stages of the HIV replication cycle, reducing viral load and helping restore immune function.
Symtuza is typically taken once daily with food. Patients should be screened for hepatitis B before starting treatment, as discontinuation of emtricitabine or tenofovir in patients with HBV can cause serious liver problems. Common side effects may include diarrhea, nausea, and rash. Patients should be monitored for kidney function and bone density, as these may be affected. Resistance testing is recommended before initiating therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy