Omacetaxine
Synribo is a brand-name injectable medication used to treat adults with chronic or accelerated phase chronic myeloid leukemia (CML) who have not responded to at least two other tyrosine kinase inhibitor therapies. As a protein synthesis inhibitor, it works by blocking abnormal protein production from the BCR-ABL fusion gene that drives leukemia cell growth.
Synribo is a treatment for certain patients with chronic myeloid leukemia who have failed other therapies.
Key facts at a glance
- RxNorm
- 1356689
- Generic
- Synribo
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Synribo is indicated for the treatment of adult patients with chronic phase or accelerated phase chronic myeloid leukemia (CML) with resistance and/or intolerance to two or more tyrosine kinase inhibitors such as imatinib, dasatinib, or nilotinib.
Synribo contains omacetaxine mepesuccinate, which inhibits protein synthesis by preventing the elongation of polypeptide chains. This targets the BCR-ABL protein responsible for uncontrolled growth of leukemia cells.
Synribo is administered by subcutaneous injection, typically twice daily for 14 consecutive days per 28-day cycle initially. Common side effects include low blood cell counts (myelosuppression), bleeding, diarrhea, nausea, fatigue, and injection site reactions. It should not be used during pregnancy. Regular blood count monitoring is required during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy