Hyaluronic Acid
Synvisc is a brand-name viscosupplementation injection used to treat osteoarthritis, primarily in the knee. It contains hyaluronic acid derivatives that help restore the lubricating and cushioning properties of synovial fluid in joints. This treatment is typically considered when conservative therapies like physical therapy or pain relievers have not provided adequate relief.
Synvisc is an injectable hyaluronic acid treatment for knee osteoarthritis that supplements joint fluid to reduce pain and improve mobility.
Key facts at a glance
- RxNorm
- 220144
- Generic
- Synvisc
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Synvisc is indicated for the treatment of osteoarthritis of the knee in patients who have not responded adequately to conservative non-pharmacological therapies and simple analgesics like acetaminophen. It may be used as an alternative to or in conjunction with other treatments when initial approaches prove insufficient.
Synvisc contains hylan polymers, which are derivatives of hyaluronic acid—a substance naturally found in joint synovial fluid. When injected into the joint space, it acts as a lubricant and shock absorber, helping to restore the viscoelastic properties of the synovial fluid and reduce pain associated with osteoarthritis.
Synvisc is administered as a series of injections (typically three injections given one week apart). It is for intra-articular use only and should be administered by a qualified healthcare professional. Common side effects may include temporary pain, swelling, or stiffness at the injection site. Patients should avoid strenuous activities for 48 hours after injection. Effectiveness varies among individuals, and benefits may last several months before repeat treatment may be considered.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy