Trientine
Syprine (trientine dihydrochloride) is a chelating agent used to treat Wilson's disease, a rare genetic disorder that causes excessive copper accumulation in the body. It works by binding to copper and facilitating its removal through urine, helping prevent organ damage to the liver, brain, and other tissues.
Syprine is a copper-chelating medication for Wilson's disease that helps remove excess copper from the body.
Key facts at a glance
- RxNorm
- 220145
- Generic
- Syprine
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of Wilson's disease (hepatolenticular degeneration) in patients who are intolerant to penicillamine therapy.
Syprine is a chelating agent that binds to excess copper in the body, forming a soluble complex that is then excreted through the kidneys in urine.
Should be taken on an empty stomach, at least one hour before or two hours after meals. Regular monitoring of copper levels and blood counts is essential. May cause iron deficiency and requires supplementation if needed. Do not take with mineral supplements as they may reduce absorption.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy