Tacalcitol
Tacalcitol is a topical vitamin D3 analog used to treat plaque psoriasis by helping to normalize the excessive growth and scaling of skin cells. It is applied directly to affected skin areas and is suitable for patients with mild to moderate plaque psoriasis who require topical therapy.
Tacalcitol is a topical psoriasis treatment that works by regulating skin cell growth and differentiation.
Key facts at a glance
- ATC
- D05AX04
- RxNorm
- 291204
- Generic
- Tacalcitol
- Class
- atc-d05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- topical
- Forms
- ointment
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tacalcitol is indicated for the topical treatment of plaque psoriasis (psoriasis vulgaris). It may be used alone or in combination with other psoriasis treatments as directed by a healthcare provider.
As a vitamin D3 analog, tacalcitol binds to vitamin D receptors in skin cells. This action helps normalize the abnormal proliferation and differentiation of keratinocytes, reducing the thick, scaly plaques characteristic of psoriasis.
Tacalcitol is for external use only and should not be applied to the face. Patients should avoid excessive sun exposure on treated areas. Calcium levels are generally not affected with topical use, but caution is needed in patients with disorders of calcium metabolism. Use during pregnancy and breastfeeding should be discussed with a healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy