Tafamidis
Tafamidis is a prescription medication used to treat transthyretin amyloidosis, a rare genetic or age-related disease where abnormal protein deposits (amyloid) accumulate in organs and tissues, particularly affecting the heart and nervous system. It works by specifically stabilizing the transthyretin protein to prevent these harmful amyloid deposits from forming.
Tafamidis stabilizes transthyretin protein to prevent amyloid formation in hereditary and wild-type transthyretin amyloidosis affecting nerves and the heart.
Key facts at a glance
- ATC
- N07XX08
- RxNorm
- 1545063
- Generic
- Tafamidis
- Class
- atc-n07
- Brands
- Vyndamax, Vyndaqel
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tafamidis is indicated for the treatment of hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) in adults, and wild-type or hereditary transthyretin amyloid cardiomyopathy (ATTR-CM) to reduce cardiovascular mortality and hospitalization.
Tafamidis is a selective TTR stabilizer that binds to the thyroxine binding sites on the transthyretin protein. This binding stabilizes the TTR tetramer structure and slows its dissociation into monomers, which is the rate-limiting step in the amyloidogenic process that leads to harmful protein deposits.
Tafamidis is taken orally once daily as a softgel capsule. Common side effects may include diarrhea, nausea, and abdominal pain. It is generally well-tolerated but should be used under physician supervision. Patients should inform their healthcare provider of any liver problems or pregnancy before starting treatment.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy