Rifaximin
Talicia is a combination prescription medication containing amoxicillin, omeprazole, and rifabutin, used to treat Helicobacter pylori (H. pylori) infection in adults. This three-drug combination works synergistically, with antibiotics killing the bacteria while the acid reducer helps create a better environment for treatment effectiveness. It is specifically indicated when H. pylori infection has been confirmed through testing.
Talicia is a prescription brand-name treatment combining three drugs to eradicate H. pylori bacteria in the stomach.
Key facts at a glance
- RxNorm
- 2262027
- Generic
- Talicia
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Talicia is used to treat duodenal ulcer disease associated with H. pylori infection and to eradicate H. pylori bacteria in adults. Diagnosis should be confirmed before initiating treatment, typically through endoscopy or non-invasive testing.
Talicia combines amoxicillin (a penicillin-type antibiotic that kills bacteria), rifabutin (an antibiotic that works by inhibiting bacterial DNA-dependent RNA polymerase), and omeprazole (a proton pump inhibitor that reduces stomach acid, creating a less hostile environment for the antibiotics to work effectively against H. pylori).
Talicia should not be used in patients with known penicillin allergy. Common side effects may include diarrhea, headache, nausea, and rash. Rifabutin may cause discoloration of body fluids. Patients should complete the full course of therapy as prescribed. Drug interactions may occur, particularly with certain antiretrovirals and other medications metabolized by liver enzymes.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy