Talazoparib
Talzenna (talazoparib) is a prescription PARP inhibitor used to treat certain types of breast cancer in adults with inherited BRCA mutations. It works by blocking the PARP enzyme, which cancer cells rely on to repair their DNA, ultimately slowing or stopping tumor growth.
Talzenna is a PARP inhibitor used to treat BRCA-mutated breast cancer by preventing cancer cells from repairing their DNA.
Key facts at a glance
- RxNorm
- 2099947
- Generic
- Talzenna
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Talzenna is approved for the treatment of adults with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm) HER2-negative locally advanced or metastatic breast cancer. It is typically used when the cancer has progressed after prior chemotherapy treatment.
Talzenna is a poly ADP-ribose polymerase (PARP) inhibitor. It works by blocking the PARP enzyme, which cancer cells with BRCA mutations depend on to repair DNA damage. By inhibiting this repair mechanism, the medication causes cancer cells to accumulate DNA damage and die.
Common side effects may include fatigue, nausea, anemia, headache, and hair loss. Patients should have BRCA mutation testing confirmed before starting treatment. Talzenna may cause bone marrow problems and should be used with caution in pregnant patients, as it can cause harm to an unborn baby. Regular blood monitoring is typically required during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy