Tarlatamab
Tarlatamab is a bispecific T-cell engager antibody used to treat adults with extensive-stage small cell lung cancer that has progressed after platinum-based chemotherapy. It works by binding to both DLL3 on cancer cells and CD3 on T cells, activating the immune system to attack and destroy tumor cells. This targeted immunotherapy offers a novel approach for patients with limited treatment options.
A bispecific antibody immunotherapy for advanced small cell lung cancer that redirects T cells to attack DLL3-expressing tumor cells.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L01FX33
- RxNorm
- 2682954
- Generic
- Tarlatamab
- Class
- atc-l01
- Brands
- Imdelltra
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of adults with extensive-stage small cell lung cancer (ES-SCLC) who have disease progression following platinum-based chemotherapy.
Tarlatamab is a bispecific T-cell engager that simultaneously binds to DLL3 on the surface of tumor cells and CD3 on T cells. This binding bridges T cells to cancer cells, triggering T-cell activation, inflammatory cytokine release, and subsequent lysis of DLL3-expressing tumor cells.
Administered as an intravenous infusion. Common adverse effects include cytokine release syndrome (CRS), fatigue, and fever. Patients should be monitored for signs of CRS during and after treatment. Requires careful patient selection and management by healthcare providers experienced in immunotherapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy