Tolcapone
Tasmar (tolcapone) is a prescription brand-name medication used as an adjunct treatment for Parkinson's disease, specifically added to levodopa/carbidopa therapy when patients experience 'wearing-off' episodes. It belongs to the COMT inhibitor drug class and helps extend the duration of levodopa's effect in the brain.
Tasmar is a COMT inhibitor used with levodopa/carbidopa to manage Parkinson's disease symptoms by prolonging levodopa's effectiveness.
Key facts at a glance
- RxNorm
- 153657
- Generic
- Tasmar
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tasmar is indicated as an adjunct to levodopa/carbidopa for the treatment of idiopathic Parkinson's disease, particularly for patients experiencing motor fluctuations or 'wearing-off' episodes despite optimized levodopa therapy.
Tasmar works by inhibiting the enzyme catechol-O-methyltransferase (COMT), which normally breaks down levodopa in the peripheral tissues. By blocking this enzyme, more levodopa reaches the brain, extending its therapeutic effect and reducing off-periods between doses.
Tasmar carries a FDA black box warning for potential severe hepatotoxicity; liver function tests are required before starting treatment and monitored regularly throughout therapy. It may cause or worsen dyskinesia, and patients should be monitored for signs of liver injury such as jaundice, dark urine, or unexplained nausea. Tasmar may interact with other medications and should only be used when other adjunct therapies are inadequate or not tolerated.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy