Tazemetostat
Tazemetostat is an oral targeted therapy that inhibits EZH2 and EZH1, enzymes involved in epigenetic gene regulation. It is approved for the treatment of adults and pediatric patients (16 years and older) with metastatic or locally advanced epithelioid sarcoma who are not eligible for complete resection, as well as for adult patients with relapsed or refractory follicular lymphoma.
Tazemetostat is an oral EZH2 inhibitor used to treat certain types of epithelioid sarcoma and follicular lymphoma.
Key facts at a glance
- ATC
- L01XX72
- RxNorm
- 2274378
- Generic
- Tazemetostat
- Class
- atc-l01
- Brands
- Tazverik
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tazemetostat is indicated for the treatment of adults and pediatric patients (16 years and older) with metastatic or locally advanced epithelioid sarcoma who are not eligible for complete resection, and for adult patients with relapsed or refractory follicular lymphoma who have no satisfactory alternative treatment options.
Tazemetostat inhibits EZH2 and EZH1, which are histone methyltransferases. By blocking these enzymes, it reduces methylation of histone H3 at lysine 27 (H3K27), leading to altered gene expression and decreased tumor cell proliferation in cancers that depend on EZH2 activity.
Tazemetostat is taken orally, typically twice daily, and may cause serious adverse effects including myelosuppression and hepatotoxicity. Regular blood monitoring is required. It may cause fetal harm and is not recommended during pregnancy. Treatment should be supervised by an oncologist experienced in anticancer therapy.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy