Tegaserod
Tegaserod is a serotonin-5-HT4 receptor agonist used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation by activating 5-HT4 receptors in the gut.
Tegaserod is a gastrointestinal prokinetic agent used to relieve constipation symptoms in IBS-C and chronic constipation.
Key facts at a glance
- ATC
- A06AX06
- RxNorm
- 139778
- Generic
- Tegaserod
- Class
- atc-a06
- Brands
- Zelnorm
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tegaserod is primarily indicated for the treatment of irritable bowel syndrome with constipation (IBS-C) in women under 65 years of age, and for chronic idiopathic constipation in adults.
As a selective 5-HT4 receptor agonist, tegaserod stimulates serotonin receptors in the gastrointestinal tract, enhancing gastric emptying, increasing intestinal motility, and promoting intestinal fluid secretion to facilitate bowel movements.
This medication was withdrawn from the US market in 2007 due to cardiovascular safety concerns. It should not be used in patients with a history of cardiovascular disease, ischemic heart disease, or stroke. Treatment is typically limited to 4-6 weeks for IBS-C. Common side effects include headache, abdominal pain, and diarrhea.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy