Inotersen
Tegsedi is a brand-name medication used to treat polyneuropathy in adults with hereditary transthyretin (hATTR) amyloidosis, a rare genetic condition that causes abnormal protein buildup in organs and nerves. It is administered as a subcutaneous injection and works by reducing the production of the transthyretin protein that causes organ damage in this condition.
Tegsedi is used to slow nerve damage progression in adults with hereditary transthyretin amyloidosis.
Key facts at a glance
- RxNorm
- 2099319
- Generic
- Tegsedi
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tegsedi is indicated for the treatment of stage 1 or stage 2 polyneuropathy in adults with hereditary transthyretin amyloidosis (hATTR). This rare genetic disorder causes abnormal amyloid protein to accumulate in various organs, particularly affecting the peripheral nervous system.
Tegsedi contains the active ingredient inotersen, an antisense oligonucleotide that specifically binds to messenger RNA (mRNA) produced by the transthyretin (TTR) gene. By targeting and degrading this mRNA, the medication reduces the production of the TTR protein, thereby limiting the formation of amyloid deposits that cause organ and nerve damage.
Tegsedi requires regular monitoring, including weekly blood tests for platelet counts and kidney function. Common side effects may include injection site reactions, nausea, and fatigue. The medication carries a boxed warning for serious risks of thrombocytopenia and glomerulonephritis, which require prompt medical attention. Patients should be monitored for vitamin A levels and liver function during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy