Tenecteplase
Tenecteplase is a fibrin-specific thrombolytic medication used in emergency settings to rapidly dissolve life-threatening blood clots. It is primarily indicated for acute ST-elevation myocardial infarction (heart attack) and may also be used for acute pulmonary embolism. The medication is administered as a single intravenous bolus injection, making it suitable for time-critical situations where prompt clot dissolution is essential.
A single-dose thrombolytic agent that breaks down blood clots in acute heart attacks and pulmonary embolism.
Key facts at a glance
- ATC
- B01AD11
- RxNorm
- 259280
- Generic
- Tenecteplase
- Class
- atc-b01
- Brands
- Tnkase
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tenecteplase is used to treat acute ST-elevation myocardial infarction (STEMI) when percutaneous coronary intervention is not available within recommended timeframes. It may also be used for acute massive pulmonary embolism with hemodynamic instability.
Tenecteplase is a genetically modified form of human tissue plasminogen activator that binds specifically to fibrin within blood clots. Once bound to fibrin, it converts plasminogen to plasmin, which then breaks down the fibrin structure and dissolves the clot.
This medication carries significant bleeding risk and is contraindicated in patients with active internal bleeding, recent surgery or trauma, history of hemorrhagic stroke, or uncontrolled hypertension. It should be administered as soon as possible after symptom onset for maximum benefit. Anticoagulant and antiplatelet medications may increase bleeding risk when used with tenecteplase.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy