Teprotumumab
Tepezza (teprotumumab) is a prescription medication used to treat thyroid eye disease, a condition where the immune system attacks the tissues around the eyes, causing inflammation, swelling, and potential eye protrusion. It is administered as an intravenous (IV) infusion and is specifically indicated for adults with moderate-to-severe thyroid eye disease.
Tepezza is a monoclonal antibody treatment for thyroid eye disease that reduces inflammation and swelling around the eyes.
Key facts at a glance
- RxNorm
- 2274808
- Generic
- Tepezza
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tepezza is FDA-approved for the treatment of thyroid eye disease (also known as Graves' ophthalmopathy) in adults with moderate-to-severe active disease. It helps reduce eye bulging, double vision, and other symptoms associated with this autoimmune condition affecting the tissues behind the eyes.
Tepezza is a monoclonal antibody that works by inhibiting insulin-like growth factor-1 (IGF-1R), a receptor involved in the inflammatory and immune responses that cause thyroid eye disease. By blocking this pathway, it reduces inflammation, swelling, and tissue expansion in the eye socket.
Tepezza is administered by intravenous (IV) infusion, typically every three weeks for a total of eight infusions. Common side effects may include muscle cramps, nausea, hair loss, and fatigue. Patients should be monitored for worsening of blood sugar levels and informe their healthcare provider of any pregnancy plans, as its effects during pregnancy are not well established.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy