Tepotinib
Tepmetko is a prescription medication used to treat adults with metastatic non-small cell lung cancer (NSCLC) that has specific genetic alterations called MET exon 14 skipping mutations. It belongs to a class of drugs called MET inhibitors and works by targeting and blocking the MET protein, which is involved in cancer cell growth and spread. This medication is typically considered when other treatments have not been effective or are not suitable options.
Tepmetko is a targeted therapy for certain types of metastatic lung cancer with MET exon 14 skipping mutations.
Key facts at a glance
- RxNorm
- 2477267
- Generic
- Tepmetko
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tepmetko is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have MET exon 14 skipping alterations. This genetic mutation leads to abnormal MET signaling that promotes cancer growth.
Tepmetko is a MET inhibitor that works by selectively blocking the activity of the MET tyrosine kinase protein. By inhibiting MET, the medication helps slow or stop the growth of cancer cells that depend on this signaling pathway for survival and spread.
Common side effects may include swelling, fatigue, nausea, and liver changes. Patients should be monitored for liver problems or lung-related side effects. Tepmetko may interact with other medications, and patients should discuss their complete medical history with their healthcare provider before starting treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy