Tepotinib
Tepotinib is an oral targeted therapy for adults with metastatic non-small cell lung cancer (NSCLC) that has spread and contains MET gene alterations, specifically exon 14 skipping mutations. As a kinase inhibitor, it works by blocking the MET protein and its signaling pathways, which are involved in cancer cell growth and spread. This medication is typically used when the cancer has progressed after other treatments.
Tepotinib is a precision cancer drug that inhibits the MET protein to treat metastatic NSCLC with MET exon 14 skipping mutations.
Key facts at a glance
- ATC
- L01EP02
- RxNorm
- 2477103
- Generic
- Tepotinib
- Class
- atc-l01
- Brands
- Tepmetko
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tepotinib is approved for treating adults with metastatic non-small cell lung cancer (NSCLC) that has MET exon 14 skipping alterations, particularly after progression on other therapies.
Tepotinib is a selective kinase inhibitor that targets the MET receptor tyrosine kinase. It blocks both HGF-dependent and HGF-independent MET phosphorylation, preventing activation of downstream signaling pathways (including PI3K/AKT and MAPK/ERK) that drive tumor cell growth, survival, and metastasis.
Common side effects include fatigue, edema, nausea, and musculoskeletal pain. Serious risks include interstitial lung disease and hepatotoxicity. Patients require monitoring during treatment. Diagnosis should be confirmed through appropriate molecular testing before starting therapy.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy