Teprotide
Tepylute is a brand-name chemotherapy medication containing treosulfan, an alkylating agent used primarily as part of conditioning regimens before hematopoietic stem cell transplantation. It works by causing DNA cross-linking in rapidly dividing cells, which helps eliminate cancer cells and suppress the immune system prior to transplant. This medication is typically reserved for patients undergoing treatment for various hematologic malignancies and certain solid tumors.
Tepylute is an alkylating chemotherapy agent used in conditioning regimens prior to stem cell transplantation for certain cancers.
Key facts at a glance
- RxNorm
- 2700702
- Generic
- Tepylute
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used as a conditioning agent before allogeneic or autologous hematopoietic stem cell transplantation in patients with hematologic malignancies such as leukemia, lymphoma, and multiple myeloma. May also be used in some solid tumor treatment protocols.
Tepylute contains treosulfan, a prodrug that is converted to active alkylating metabolites. These metabolites cause DNA cross-linking, preventing DNA replication and cell division. This cytotoxic effect targets rapidly dividing cells, including cancer cells and immune cells, preparing the patient's body for stem cell transplantation.
As a cytotoxic chemotherapy agent, Tepylute carries significant risks including myelosuppression, hepatotoxicity, and increased susceptibility to infections. It should only be administered under the supervision of oncologists experienced in stem cell transplantation. Use requires careful patient selection, and it is contraindicated in patients with known hypersensitivity to treosulfan or severe organ dysfunction. Close monitoring of blood counts and organ function is essential during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy