Thalidomide
Thalomid (thalidomide) is an immunomodulatory drug used to treat certain inflammatory conditions and cancers. It is primarily prescribed for erythema nodosum leprosum, a complication of leprosy, and for multiple myeloma, often in combination with other therapies.
Thalomid is an immunomodulatory medication used for leprosy complications and multiple myeloma, but carries significant safety risks including severe birth defects.
Key facts at a glance
- RxNorm
- 220239
- Generic
- Thalomid
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Thalomid is FDA-approved for the treatment of erythema nodosum leprosum (ENL), an inflammatory complication of leprosy, and is also used in combination therapy for multiple myeloma, a type of blood cancer.
Thalomid works as an immunomodulatory agent by inhibiting inflammatory cytokines like TNF-alpha, modulating immune system activity, and inhibiting angiogenesis (the formation of new blood vessels that feed tumors).
Thalomid is a known teratogen causing severe birth defects and is absolutely contraindicated in pregnancy. It requires enrollment in a restricted distribution program. Common side effects include peripheral neuropathy, drowsiness, and an increased risk of blood clots. Patients should use effective contraception and undergo regular neurological monitoring.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy