Thiabendazole
Thiabendazole is an anthelmintic (anti-parasitic) medication used to treat various worm infections, including strongyloidiasis (threadworm) and cutaneous larva migrans (creeping eruption). It works by inhibiting the energy metabolism of parasites, effectively eliminating them from the body. This medication is available by prescription and is typically taken orally.
Thiabendazole is an anti-parasitic medication used to treat worm infections like threadworm and creeping eruption.
Key facts at a glance
- ATC
- D01AC06
- RxNorm
- 10450
- Generic
- Thiabendazole
- Class
- atc-d01
- Brands
- Tresaderm
- Availability
- rx
- Lactation
- unknown
- Routes
- topical, oral
- Forms
- solution, suspension, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
11 groupspregnancy
first trimesteravoid if possible
avoid use during pregnancy unless benefits outweigh risks
regular fetal monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
second trimesteruse lowest effective dose
use only if clearly needed and benefits outweigh risks
fetal ultrasound monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimesteruse lowest effective dose
use only if clearly needed
fetal monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingdiscontinue breastfeeding or avoid drug
thiabendazole passes into breast milk; breastfeeding mothers should either discontinue nursing or avoid this medication
monitor infant for adverse effects
Use of this medication in this population requires careful consideration of risks and benefits.
pediatric_age
children under 15 kgweight-based dosing required
use with caution; dose based on body weight; not recommended for children under 15 kg
monitor for gastrointestinal and CNS effects
Use with caution and monitor for adverse effects.
pediatric_age
children 15 40 kgweight-based dosing 25 mg/kg every 12 hours
dose should not exceed 3 g daily; use for minimum duration
monitor liver function and for CNS symptoms
Use with caution and monitor for adverse effects.
geriatric
elderly 65 years and olderstart with lower dose
use with caution; consider renal and hepatic function; monitor for adverse CNS effects
monitor renal and hepatic function
Use with caution and monitor for adverse effects.
renal_impairment
mild renal impairmentno initial adjustment needed
use with caution; monitor renal function
periodic renal function monitoring
Use with caution and monitor for adverse effects.
renal_impairment
severe renal impairmentreduce dose and increase dosing interval
use with caution; dose reduction recommended
close renal function monitoring and drug level monitoring if available
Use with caution and monitor for adverse effects.
hepatic_impairment
mild hepatic impairmentuse with caution
use with caution; monitor liver function tests
regular liver function monitoring
Use with caution and monitor for adverse effects.
hepatic_impairment
severe hepatic impairmentavoid if possible
avoid use in severe hepatic impairment due to risk of toxicity
liver function monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
Statistics and clinical data
Drug class
Drug class information for Thiabendazole (antiparasitic agent)
First FDA approval
Initial FDA approval year for Thiabendazole
Mechanism of action
Primary pharmacological mechanism of action
Common therapeutic uses
Primary indications for Thiabendazole treatment
Thiabendazole is primarily used to treat strongyloidiasis (intestinal threadworm infection), cutaneous larva migrans (a skin infection caused by hookworm larvae), and other helminth infections including trichinosis and visceral larva migrans.
Thiabendazole works by inhibiting the enzyme fumarate reductase in parasites, which disrupts their energy metabolism and ability to survive. This leads to the death and elimination of the parasites from the body.
Common side effects include nausea, vomiting, and dizziness. Patients with liver disease should use this medication with caution. Thiabendazole may interact with other medications, and blood counts should be monitored during prolonged treatment. It is contraindicated in patients with known hypersensitivity to the drug.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy