Thioguanine
Thioguanine is a purine analog antimetabolite used primarily in the treatment of certain types of leukemia, particularly acute myeloid leukemia (AML). It works by interfering with DNA and RNA synthesis in rapidly dividing cells, including cancer cells and immune cells. The medication may also be used in some autoimmune conditions such as inflammatory bowel disease.
Thioguanine is a chemotherapy agent that disrupts DNA synthesis in cancer and immune cells, primarily used for acute leukemia.
Key facts at a glance
- ATC
- L01BB03
- RxNorm
- 10485
- Generic
- Thioguanine
- Class
- atc-l01b
- Brands
- Tabloid
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Thioguanine is primarily used in the treatment of acute myeloid leukemia (AML) and other leukemias, particularly in combination chemotherapy regimens. It may also be used for certain autoimmune conditions such as inflammatory bowel disease when other treatments have not been effective.
Thioguanine is a purine analog that interferes with purine synthesis, a essential process for DNA and RNA production. Once metabolized in the body, it forms active thioguanine nucleotides that become incorporated into DNA and RNA strands, causing errors in genetic material replication and ultimately preventing cell division and growth.
Thioguanine can cause significant bone marrow suppression, requiring regular blood monitoring. Liver function should also be monitored regularly due to potential hepatotoxicity. Patients should be monitored closely for signs of infection or unusual bleeding. The medication should be used with caution in patients with liver or kidney impairment. Effective contraception is recommended during treatment due to potential harm to unborn babies.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy