Tiopronin
Thiola (tiopronin) is a prescription brand-name medication used to prevent recurring cystine kidney stones in adults and children weighing at least 44 pounds. It works by binding to cystine in the urine, forming a more soluble compound that helps prevent stone formation.
Thiola is used to prevent painful cystine kidney stones from forming.
Key facts at a glance
- RxNorm
- 227253
- Generic
- Thiola
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Thiola is indicated for the prevention of recurrent cystine nephrolithiasis (kidney stones) in patients with homozygous cystinuria, a genetic condition that causes high levels of cystine in the urine leading to stone formation.
Thiola contains tiopronin, a thiol compound that reacts with cystine in the urine to form a soluble complex, reducing cystine concentration and preventing the crystallization and stone formation that occurs in cystinuria.
Thiola may cause gastrointestinal upset, fever, or skin reactions. Patients should maintain adequate fluid intake (typically 3+ liters daily) while taking this medication. Regular monitoring of urine cystine levels and kidney function is recommended. Should not be used during pregnancy unless clearly needed.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy