Antithrombin III
Thrombate III is a concentrated form of antithrombin III (AT III), a natural protein in the blood that helps prevent excessive clotting. It is primarily used to treat patients with hereditary antithrombin deficiency who are at risk for or experiencing blood clots, particularly during high-risk situations such as surgery or pregnancy.
Thrombate III replaces deficient antithrombin III to prevent blood clots in patients with hereditary AT III deficiency.
Key facts at a glance
- RxNorm
- 220305
- Generic
- Thrombate Iii
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of thromboembolism in patients with hereditary antithrombin III deficiency, particularly during surgical procedures, childbirth, or when patients are at high risk for blood clots.
Thrombate III provides exogenous antithrombin III, a natural inhibitor of clotting factors (primarily thrombin and factor Xa), thereby enhancing the body's natural anticoagulation pathway to prevent excessive clot formation.
Derived from human plasma, so viral infection risk cannot be completely excluded. Dosing is individualized based on weight and AT III levels. Requires regular monitoring of AT III activity levels. May interact with heparin anticoagulants. Not for use in patients with known hypersensitivity to human plasma products.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy