Anti-thymocyte Globulin
Thymoglobulin is an immunosuppressant medication containing rabbit-derived antibodies that target and deplete T-lymphocytes, key cells in the immune system's attack on transplanted organs. It is used to prevent or treat acute rejection in patients receiving organ transplants, particularly kidney transplants, and is also used to treat severe aplastic anemia when other treatments have not been effective.
An immunosuppressant that depletes T-cells to prevent organ rejection and treat severe aplastic anemia.
Key facts at a glance
- RxNorm
- 225741
- Generic
- Thymoglobulin
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention and treatment of acute rejection in solid organ transplantation (especially kidney); treatment of moderate to severe aplastic anemia in patients who have not responded to conventional immunosuppressive therapy.
A polyclonal anti-thymocyte antibody preparation that binds to multiple T-cell surface antigens, leading to T-lymphocyte depletion through complement-mediated lysis and antibody-dependent cellular cytotoxicity, thereby reducing the immune response against transplanted organs.
Administered intravenously in a hospital setting with appropriate monitoring. Common side effects include infusion reactions (fever, chills, rash), leukopenia, and increased risk of infections and malignancy. Patients require careful monitoring of blood counts and infection signs during treatment. May increase susceptibility to cytomegalovirus and other viral infections.
Official drug label
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If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy