Tibolone
Tibolone is a synthetic steroid medication used primarily for hormone replacement therapy in postmenopausal women. It has combined estrogenic, progestogenic, and androgenic properties, making it useful for managing menopausal symptoms such as hot flashes, vaginal dryness, and mood changes. It may also help prevent bone loss associated with menopause.
Tibolone is a combined hormone therapy used to treat menopausal symptoms in women, functioning as a synthetic steroid with estrogenic, progestogenic, and androgenic effects.
Key facts at a glance
- ATC
- G03CX01
- RxNorm
- 38260
- Generic
- Tibolone
- Class
- atc-g03
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tibolone is prescribed for the relief of menopausal symptoms in postmenopausal women, including vasomotor symptoms like hot flashes and night sweats, vaginal dryness, and mood disturbances. It is also used to prevent postmenopausal osteoporosis. Some formulations are used in transgender hormone therapy.
Tibolone acts through its metabolites, which have estrogenic effects on bone and vaginal tissue, progestogenic effects on the endometrium, and androgenic effects on sexual function and mood. Its tissue-selective activity allows it to provide symptomatic relief while maintaining a favorable safety profile.
Common side effects may include breakthrough bleeding, breast tenderness, headache, and abdominal pain. It is contraindicated in patients with known or suspected hormone-sensitive cancers, unexplained vaginal bleeding, or severe liver disease. Regular monitoring for breast abnormalities and cardiovascular risk factors is recommended during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy