Tibsovo
Tibsovo (ivosidenib) is a targeted therapy medication used to treat certain types of acute myeloid leukemia (AML) in adults who have a specific genetic mutation called IDH1. It works by inhibiting the mutated IDH1 enzyme, which helps control the growth of cancer cells. This medication is typically used when the cancer has returned after treatment (relapsed) or has not responded to initial therapy (refractory).
Tibsovo is a prescription cancer medication that targets acute myeloid leukemia cells with an IDH1 mutation.
Key facts at a glance
- RxNorm
- 2049879
- Generic
- Tibsovo
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of adults with relapsed or refractory acute myeloid leukemia (AML) with an IDH1 mutation, as detected by an FDA-approved test. May also be used in newly diagnosed AML patients age 75+ or with comorbidities preventing intensive chemotherapy.
Tibsovo is an IDH1 inhibitor that targets and blocks the mutated IDH1 enzyme, which is involved in cancer cell growth and differentiation.
Can cause differentiation syndrome (a serious condition requiring prompt treatment), QT prolongation (heart rhythm changes), and Guillain-Barré syndrome. Liver function should be monitored during treatment. Take with or without food; avoid high-fat meals. Inform your doctor about all medications, as drug interactions may occur.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy