Tisagenlecleucel
Tisagenlecleucel (KYMRIAH) is a personalized cell-based immunotherapy that reprograms a patient's own immune cells to recognize and destroy cancer cells. It is used to treat certain blood cancers, including acute lymphoblastic leukemia in children and young adults, and large B-cell lymphoma in adults who have not responded to other treatments.
Tisagenlecleucel is a CAR-T cell therapy that uses a patient's own genetically modified immune cells to target and eliminate cancer cells.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L01XL04
- RxNorm
- 1986438
- Generic
- Tisagenlecleucel
- Class
- atc-l01
- Brands
- Kymriah
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats relapsed or refractory B-cell acute lymphoblastic leukemia (ALL) in patients up to 25 years of age, and relapsed or refractory diffuse large B-cell lymphoma (DLBCL) in adults.
A patient's T cells are collected and genetically engineered to express a chimeric antigen receptor (CAR) that targets the CD19 protein found on the surface of B cells. When reinfused, these modified cells identify and destroy cancer cells and normal B cells.
Administered as a single infusion at a certified treatment center. Serious side effects include cytokine release syndrome (CRS) and neurological toxicities. Patient's own cells are used (autologous), so treatment requires careful coordination and timing.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy