Tisseel
Tisseel is a brand-name fibrin sealant used during surgical procedures to control bleeding and seal tissues. It is applied topically to surgical sites where conventional hemostatic methods are insufficient. This medication is used across multiple surgical specialties, including cardiovascular, general, and orthopedic surgery.
Tisseel is a fibrin-based surgical sealant that helps control bleeding and seal tissues during various surgical procedures.
Key facts at a glance
- RxNorm
- 287575
- Generic
- Tisseel
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tisseel is used as a hemostatic agent and tissue sealant in surgical procedures where standard bleeding control methods are inadequate or impractical. It is commonly used in cardiovascular surgery, general surgery, orthopedic surgery, and other procedures requiring tissue adhesion or hemostasis.
Tisseel is a two-component fibrin sealant containing human fibrinogen and thrombin. When the two components are mixed, thrombin converts fibrinogen into fibrin, which then cross-links to form a stable clot at the application site. This mimics the final stage of the body's natural coagulation cascade, creating both a mechanical barrier and a seal.
Tisseel should only be administered by healthcare professionals trained in its use. It must not be injected into blood vessels or tissues, as this may cause thromboembolic events. The product is contraindicated in patients with known hypersensitivity to human blood products. Application should be precise to avoid unintended adhesion.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy