Tivozanib
Tivozanib is a tyrosine kinase inhibitor used to treat advanced renal cell carcinoma (kidney cancer) in adults. It works by blocking the action of vascular endothelial growth factor (VEGF) receptors, which are involved in tumor blood vessel formation and cancer growth.
Tivozanib is a targeted cancer therapy that inhibits VEGF receptors to treat advanced kidney cancer.
Key facts at a glance
- ATC
- L01EK03
- RxNorm
- 2534233
- Generic
- Tivozanib
- Class
- atc-l01
- Brands
- Fotivda
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tivozanib is indicated for the treatment of adult patients with advanced renal cell carcinoma (kidney cancer) who have received prior anti-angiogenic therapy.
As a tyrosine kinase inhibitor, tivozanib blocks VEGF receptors (VEGFR-1, VEGFR-2, and VEGFR-3) on cancer cells and blood vessels, inhibiting tumor angiogenesis (new blood vessel formation) and slowing cancer growth. It also inhibits related kinases including c-kit and PDGFRβ.
Common side effects include hypertension, fatigue, dysphonia (hoarseness), diarrhea, nausea, and decreased appetite. Serious adverse events may include cardiac failure, arterial thromboembolic events, venous thromboembolism, hemorrhage, and proteinuria. Regular blood pressure monitoring and cardiac function assessment are recommended during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy