Tnkase
TNKase (tenecteplase) is a thrombolytic medication used to dissolve blood clots in patients experiencing acute ST-elevation myocardial infarction (STEMI), a type of heart attack. It works by activating the body's natural clot-dissolving system and is administered as a single intravenous injection.
TNKase is an emergency clot-dissolving medication used to treat acute heart attacks by restoring blood flow to the heart muscle.
Key facts at a glance
- RxNorm
- 284879
- Generic
- Tnkase
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
TNKase is indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to reduce mortality and cardiovascular complications. It is typically used when prompt percutaneous coronary intervention (PCI) is not available within appropriate timeframes.
Tenecteplase is a recombinant tissue plasminogen activator that binds to fibrin within blood clots and converts plasminogen to plasmin. This plasmin then breaks down the fibrin meshwork of the clot, restoring blood flow through the occluded coronary artery.
TNKase carries a significant risk of bleeding, including potentially life-threatening intracranial hemorrhage. It is contraindicated in patients with active internal bleeding, recent surgery, history of stroke, or uncontrolled hypertension. The medication is dosed based on patient body weight and administered as a single IV bolus over 5 seconds.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy