Totect
Totect (dexrazoxane) is a cardioprotective agent used to prevent heart damage associated with anthracycline chemotherapy drugs like doxorubicin. It is also indicated for the treatment of anthracycline extravasation, a complication where the chemotherapy drug leaks into surrounding tissue during administration.
Totect protects the heart from chemotherapy-induced damage and treats leakage of cancer drugs into surrounding tissue.
Key facts at a glance
- RxNorm
- 731011
- Generic
- Totect
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of anthracycline-induced cardiotoxicity in patients with metastatic breast cancer receiving doxorubicin; treatment of anthracycline extravasation to prevent tissue damage
Acts as an intracellular iron chelator that prevents the formation of free radicals generated by anthracycline chemotherapy, which are responsible for cardiac damage
Should be administered before anthracycline chemotherapy; for extravasation, should be given as soon as possible within 24 hours of the leak; may cause bone marrow suppression; efficacy decreases if given more than 24 hours after extravasation
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy