Tpoxx
Tpoxx (tecovirimat) is a brand-name antiviral medication approved for the treatment of smallpox in adults and children. It was developed as a medical countermeasure against potential smallpox-related bioterrorism threats and has also received emergency use authorization for related orthopoxvirus infections.
Tpoxx is an antiviral medication used to treat smallpox and related orthopoxvirus infections.
Key facts at a glance
- RxNorm
- 2055110
- Generic
- Tpoxx
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of smallpox (caused by Variola virus) in adults and pediatric patients. It has also received emergency use authorization for treatment of mpox (formerly monkeypox) and other orthopoxvirus infections in certain circumstances.
The specific mechanism is not publicly disclosed, but tecovirimat is known to inhibit the VP37 protein, which is essential for the formation and release of extracellular enveloped virus particles from infected cells, thereby preventing viral spread.
Tpoxx was approved under the FDA's Animal Rule, which allows approval based on animal efficacy studies when human trials are not feasible or ethical. It is not a substitute for smallpox vaccination. Common side effects may include headache, nausea, and abdominal pain. Patients should inform their healthcare provider of all medications being taken due to potential drug interactions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy