Tracleer
Tracleer (bosentan) is a prescription medication classified as an endothelin receptor antagonist. It works by blocking the action of endothelin, a substance in the body that causes blood vessels to narrow. This medication is used to treat certain types of pulmonary arterial hypertension and to reduce the number of new digital ulcers in patients with systemic sclerosis.
Tracleer is used to treat pulmonary arterial hypertension and systemic sclerosis-related digital ulcers by blocking endothelin receptors.
Key facts at a glance
- RxNorm
- 323502
- Generic
- Tracleer
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tracleer is primarily used to treat pulmonary arterial hypertension (PAH) to improve exercise capacity and symptoms, and to reduce the number of new digital (finger) ulcers in patients with systemic sclerosis (scleroderma).
Tracleer is an endothelin receptor antagonist that blocks endothelin-1 (ET-1), a potent vasoconstrictor and pro-fibrotic substance. By blocking ET-1 receptors, it allows blood vessels to relax and widens them, reducing pulmonary blood pressure and improving blood flow.
Tracleer is a specialty medication available only through restricted distribution programs due to potential liver toxicity and teratogenic effects. Regular liver function monitoring and monthly pregnancy tests are required. It may cause fluid retention, anemia, and interacts with multiple medications including hormonal contraceptives and certain antifungal drugs.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy