Trametinib
Trametinib is a targeted cancer therapy that inhibits MEK1 and MEK2 proteins, which are key regulators of cell proliferation in the MAPK signaling pathway. It is used to treat certain melanomas, non-small cell lung cancers, and anaplastic thyroid cancers with specific BRAF mutations, either alone or in combination with other agents.
Trametinib is a MEK inhibitor used to treat cancers with BRAF mutations by blocking cell growth signaling pathways.
Key facts at a glance
- ATC
- L01EE01
- RxNorm
- 1425099
- Generic
- Trametinib
- Class
- atc-l01
- Brands
- Mekinist
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Trametinib is indicated for unresectable or metastatic melanoma with BRAF V600E or V600K mutations, metastatic non-small cell lung cancer with BRAF V600E mutation, and anaplastic thyroid cancer with no satisfactory alternative treatments. It may be used as monotherapy or in combination with dabrafenib.
Trametinib is a reversible inhibitor of MEK1 and MEK2 kinases, blocking both activation and kinase activity. MEK proteins are upstream regulators of the ERK pathway, which controls cell proliferation and survival; by inhibiting this pathway, trametinib prevents cancer cell growth.
Patient selection requires confirmed BRAF mutation status through FDA-approved testing. Common adverse effects include rash, diarrhea, fatigue, and peripheral edema. Serious risks include cardiomyopathy, retinal vein occlusion, and interstitial lung disease. Regular cardiac monitoring and eye examinations are recommended during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy