Tranylcypromine
Tranylcypromine is a potent antidepressant medication classified as a monoamine oxidase inhibitor (MAOI). It works by irreversibly inhibiting the enzyme monoamine oxidase in the central nervous system, thereby increasing levels of monoamine neurotransmitters such as serotonin, norepinephrine, and dopamine. This medication is primarily used to treat major depressive disorder in patients who have not responded to other antidepressant therapies.
An irreversible monoamine oxidase inhibitor (MAOI) antidepressant used for treatment-resistant depression.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N06AF04
- RxNorm
- 10734
- Generic
- Tranylcypromine
- Class
- atc-n06
- Brands
- Parnate
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tranylcypromine is indicated for the treatment of major depressive disorder, particularly in cases where patients have not responded adequately to other antidepressant medications.
Tranylcypromine irreversibly inhibits monoamine oxidase (MAO), the enzyme responsible for breaking down monoamine neurotransmitters. This inhibition leads to increased concentrations of serotonin, norepinephrine, and dopamine in the synaptic cleft, enhancing neurotransmission and mood regulation.
As with all MAOIs, tranylcypromine requires strict dietary restrictions to avoid hypertensive crisis. Patients must avoid tyramine-rich foods such as aged cheeses, cured meats, fermented products, and certain alcoholic beverages. This medication carries significant risk of drug interactions and should only be used under close medical supervision by clinicians experienced with MAOI therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy