Trexall
Trexall is a brand-name formulation of methotrexate, a prescription medication available in both oral and injectable forms. It is primarily used to treat certain cancers such as acute lymphoblastic leukemia, as well as autoimmune conditions including rheumatoid arthritis and psoriasis when used at lower doses.
Trexall is a chemotherapy and immunosuppressant medication used to treat specific cancers and autoimmune diseases.
Key facts at a glance
- RxNorm
- 284900
- Generic
- Trexall
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Trexall is FDA-approved for treating acute lymphoblastic leukemia, lymphomas, and other solid tumors, as well as being used off-label for autoimmune conditions such as rheumatoid arthritis and psoriasis at lower doses.
As a folate antagonist antimetabolite, methotrexate inhibits dihydrofolate reductase, disrupting DNA and RNA synthesis in rapidly dividing cells, which helps suppress cancer cell growth and modulate immune response in autoimmune conditions.
Trexall should not be used during pregnancy due to risk of fetal harm. Regular blood monitoring is required due to risks of bone marrow suppression, liver toxicity, and kidney damage. Patients should avoid live vaccines while taking this medication.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy