Treximet
Treximet is a prescription medication combining sumatriptan and naproxen sodium, used to treat acute migraine attacks in adults. The combination targets migraine symptoms through two different mechanisms, providing relief from headache pain and associated symptoms like nausea and sensitivity to light and sound.
Treximet is a combination medication used to treat acute migraine headaches in adults by combining a triptan with an NSAID.
Key facts at a glance
- RxNorm
- 794765
- Generic
- Treximet
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treximet is indicated for the acute treatment of migraine attacks with or without aura in adults. It is not used for migraine prevention and should not be used for other types of headaches.
Treximet combines two active ingredients: sumatriptan, which binds to serotonin receptors causing vasoconstriction of cranial blood vessels and reducing inflammation, and naproxen sodium, an NSAID that provides additional analgesic and anti-inflammatory effects. Together they address multiple pathways involved in migraine pain.
Treximet should not be used by patients with cardiovascular disease, uncontrolled hypertension, or those with a history of stroke or transient ischemic attack. It is contraindicated in late pregnancy and should not be taken with MAO inhibitors or within 24 hours of other triptans or ergot-containing medications. Common side effects may include dizziness, drowsiness, nausea, and chest discomfort.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy