Tri-Heart Plus
Tri-Heart Plus is a brand-name oral heartworm preventive medication for dogs and cats. It combines two antiparasitic agents, ivermectin and pyrantel pamoate, to protect against heartworms while also controlling intestinal roundworms and hookworms. This monthly chewable tablet is administered year-round or seasonally depending on geographic risk factors.
Tri-Heart Plus is a monthly oral heartworm preventive for pets that also treats and controls intestinal worm infections.
Key facts at a glance
- RxNorm
- 1423668
- Generic
- Tri-Heart Plus
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevents heartworm disease (Dirofilaria immitis) in dogs and cats, and treats and controls infections caused by adult roundworms (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala).
Ivermectin works by disrupting the nervous system of parasitic larvae, preventing heartworm larvae from developing into adults. Pyrantel pamoate acts as a neuromuscular blocking agent against intestinal parasites, causing paralysis and elimination of worms.
A veterinarian prescription is required. Prior to starting, dogs should be tested for existing heartworm infection. Some dog breeds (particularly Collies and related) may be more sensitive to ivermectin. Administer with food to ensure proper absorption. Do not use in puppies under 6 weeks of age. Common side effects are rare but may include lethargy, vomiting, or diarrhea.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy