Tri-Luma
Tri-Luma is a topical combination medication used to treat melasma, a common skin condition causing dark, discolored patches on the face. It contains three active ingredients that work together to lighten hyperpigmented areas of the skin. This prescription medication is typically applied to affected areas once daily.
Tri-Luma is a prescription topical cream combining three active ingredients to treat melasma and reduce skin discoloration.
Key facts at a glance
- RxNorm
- 353031
- Generic
- Tri-Luma
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tri-Luma is FDA-approved for the short-term treatment of moderate to severe melasma, particularly when accompanied by signs of inflammation. It is indicated for use on the face and may be prescribed when other treatments have been ineffective.
Tri-Luma combines three complementary agents: a corticosteroid reduces inflammation and suppresses melanin production, a hydroquinone inhibits the enzyme tyrosinase to decrease melanin synthesis, and a retinoid helps increase skin cell turnover to promote even skin tone.
Tri-Luma should only be used under medical supervision as prolonged use of topical corticosteroids may cause skin thinning. It is not recommended during pregnancy and should be used with caution in patients with sensitive skin. Sun exposure should be minimized during treatment as UV light can worsen melasma.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy