Trientine
Trientine is a chelating agent primarily used to treat Wilson's disease, a rare genetic disorder that causes excessive copper accumulation in the body. It works by binding to excess copper in the bloodstream and facilitating its removal through urine. Trientine is typically prescribed when patients cannot tolerate penicillamine, another chelating agent used for the same condition.
Trientine is a copper-chelating medication used to treat Wilson's disease by removing excess copper from the body.
Key facts at a glance
- ATC
- A16AX12
- RxNorm
- 10798
- Generic
- Trientine
- Class
- atc-a16
- Brands
- Syprine, Cuvrior
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Wilson's disease (hepatolenticular degeneration) in patients who are intolerant to penicillamine. It treats the hepatic (liver) and neurological manifestations of copper toxicity.
Trientine is a copper chelator that binds to excess copper in the blood, forming a water-soluble complex that is then excreted primarily through the kidneys into urine, thereby reducing copper levels in tissues.
Should be taken on an empty stomach, at least one hour before or two hours after meals. Regular monitoring of copper levels, liver function, and blood counts is essential. Do not take with iron supplements or mineral-containing products as they may reduce absorption. Side effects may include gastrointestinal disturbances and, rarely, neurological worsening. Must be used under close medical supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy