Trifarotene
Trifarotene is a topical retinoid medication used to treat acne vulgaris. It works by selectively activating retinoic acid receptor (RAR)-gamma, which helps normalize skin cell differentiation and reduce inflammation to unclog pores and decrease acne lesions.
Trifarotene is a topical retinoid cream used to treat acne vulgaris by activating specific receptors that reduce inflammation and normalize skin cell turnover.
Key facts at a glance
- ATC
- D10AD06
- RxNorm
- 2205637
- Generic
- Trifarotene
- Class
- atc-d10
- Brands
- Aklief
- Availability
- rx
- Lactation
- unknown
- Routes
- topical
- Forms
- cream
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Trifarotene is FDA-approved for the topical treatment of acne vulgaris (common acne) in patients 9 years of age and older. It is applied to the face and/or trunk where acne lesions are present.
Trifarotene is a selective agonist of retinoic acid receptor gamma (RAR-γ). When applied topically, it activates these receptors, which modulates genes involved in cell differentiation and inflammatory responses. This helps normalize skin cell turnover, prevent pore clogging, and reduce the formation of acne lesions.
Trifarotene is for topical use only and should not be applied to eyes, lips, or mucous membranes. Common side effects include skin dryness, irritation, redness, and peeling at the application site. Patients should use sunscreen and limit sun exposure during treatment. Pregnant women should avoid handling this medication due to potential teratogenic effects.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy