Trifluoperazine
Trifluoperazine is a first-generation antipsychotic medication belonging to the phenothiazine class, primarily used to manage symptoms of psychotic disorders such as schizophrenia and short-term treatment of anxiety. It works by blocking dopamine receptors in the brain, helping to reduce hallucinations, delusions, and agitation.
An antipsychotic medication used to treat schizophrenia and anxiety by blocking dopamine activity in the brain.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N05AB06
- RxNorm
- 10800
- Generic
- Trifluoperazine
- Class
- atc-n05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- solution, tablet, suspension, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of schizophrenia and other psychotic disorders, short-term management of moderate to severe anxiety, and control of nausea and vomiting.
Blocks dopamine D2 receptors in the brain's mesolimbic pathway, reducing dopaminergic neurotransmission and alleviating positive symptoms of psychosis such as hallucinations and delusions.
May cause drowsiness, extrapyramidal symptoms (movement disorders), and orthostatic hypotension. Avoid alcohol and inform your doctor of any history of heart disease, liver problems, or seizures. Regular monitoring may be required during long-term treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy