Trifluridine
Trifluridine is a topical antiviral medication used to treat eye infections caused by herpes simplex virus (HSV). It works by inhibiting viral DNA synthesis, helping to control keratitis and keratoconjunctivitis infections of the cornea and conjunctiva. This medication is typically prescribed as eye drops for ophthalmic use only.
Trifluridine is an antiviral eye drop used to treat herpes simplex virus infections of the eye.
Key facts at a glance
- ATC
- S01AD02
- RxNorm
- 10803
- Generic
- Trifluridine
- Class
- atc-s01a
- Brands
- Lonsurf
- Availability
- rx
- Lactation
- unknown
- Routes
- oral, ophthalmic
- Forms
- tablet, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Trifluridine is primarily indicated for the treatment of epithelial keratitis and keratoconjunctivitis caused by herpes simplex virus (HSV). It is used for both primary and recurrent ocular HSV infections, including dendritic ulcers of the cornea.
Trifluridine is a thymidine analog that interferes with viral DNA synthesis. Once incorporated into viral DNA, it inhibits DNA replication and prevents the virus from multiplying, helping to control the infection and reduce inflammation in the eye.
Trifluridine is for ophthalmic topical use only and should not be injected into the eye. Common side effects may include temporary burning, stinging, or irritation upon application. Prolonged use may cause superficial punctate keratopathy or epithelial toxicity. Patients should follow dosing instructions carefully and complete the full course of treatment as prescribed.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy