Trilostane
Trilostane is a synthetic steroid that inhibits the enzyme 3 beta-hydroxysteroid dehydrogenase, reducing the production of cortisol and other adrenal steroids. It is primarily used in veterinary medicine to manage hyperadrenocorticism (Cushing's disease) in dogs by controlling excessive cortisol production.
Trilostane is an adrenal steroid synthesis inhibitor used primarily to treat Cushing's disease in dogs by reducing cortisol production.
Key facts at a glance
- ATC
- H02CA01
- RxNorm
- 38668
- Generic
- Trilostane
- Class
- atc-h02
- Brands
- Vetoryl
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used to treat pituitary-dependent hyperadrenocorticism (Cushing's disease) in dogs. May also be used in cats and occasionally in humans for adrenal disorders in specialized settings.
Inhibits 3 beta-hydroxysteroid dehydrogenase, an enzyme essential for the synthesis of cortisol, aldosterone, and androgens in the adrenal cortex. By blocking this enzyme, trilostane reduces excessive hormone production characteristic of Cushing's syndrome.
Requires monitoring of electrolytes and adrenal function during treatment. Contraindicated in animals with primary adrenal insufficiency. Should not be used in pregnant animals. Regular veterinary monitoring is essential to adjust dosage and assess treatment efficacy. May cause mild GI upset initially. Must be distinguished from adrenal-dependent Cushing's before initiating therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy