Trimeprazine
Trimeprazine is a phenothiazine-derived antihistamine with sedative properties used primarily for the symptomatic relief of allergic conditions and pruritus (itching). It possesses anticholinergic and antiemetic effects in addition to its antihistamine activity. This medication is available in various forms including tablets and oral solutions.
Trimeprazine is an antihistamine used to treat allergies and itching with added sedative effects.
Key facts at a glance
- ATC
- R06AD01
- RxNorm
- 10825
- Generic
- Trimeprazine
- Class
- atc-r06
- Brands
- Cortamine, Temaril-P
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Trimeprazine is used to treat allergic conditions such as hay fever and allergic skin reactions, pruritus (itching) associated with various conditions, and may provide sedation and antiemetic effects. It has been used in pediatric populations for its antihistamine and calming properties.
As an H1 receptor antagonist, Trimeprazine blocks the action of histamine at peripheral H1 receptors, reducing allergic symptoms. Being a phenothiazine derivative, it also has effects on other neurotransmitter systems contributing to its sedative and antipruritic properties.
Common side effects include drowsiness and sedation due to its central nervous system effects. Anticholinergic effects such as dry mouth and blurred vision may occur. Use with caution in patients with glaucoma, urinary retention, or respiratory conditions. Alcohol and other CNS depressants may enhance sedative effects.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy